Former Toronto Symphony Orchestra director Seiji Ozawa has died.

He was named permanent director of the TSO in 1965 and also helmed the San Francisco Symphony before spending almost 30-years as music director of the Boston Symphony.

The Seiji Ozawa International Academy in Switzerland says the maestro died Tuesday at his home in Tokyo.  A cause was not provided, but it’s known Ozawa had under gone treatment for esophageal cancer in 2010 and had been in ill health for some time.

Seiji Ozawa was 88.